Skin Symptoms of Cow'S Milk Protein Allergy.

Rash is extremely common and perfectly normal in babies. A newborn infant’s skin may go through a number of changes during the first four weeks of life and this is just a consequence of their sensitive skin adapting to a new and very different environment. 

Most of these changes are benign and self-limiting and will resolve without any need for treatment.1


Atopic dermatitis is a common rash also experienced by infants, however it usually occurs after they have been exposed to one or more allergens.2

The most common rashes in newborn infants are transient vesiculopustular rashes that can be diagnosed clinically based on their distinctive appearances.1 These include:

  • Erythema toxicum neonatorum: the most common rash in newborn babies with an incidence of up to 70%.3
  • Acne neonatorum: typically affects up to 20% of newborn babies.1
  • Transient neonatal pustular melanosis: an idiopathic pustular eruption.4

Other common rashes include:

  • Milia - it occurs in up to 50% of newborn babies and usually disappears within the first month of life.5
  • Miliaria (heat rash) - affects up to 40% of newborn babies and usually appears during the first month of life.6
  • Seborrheic dermatitis - extremely common and should not be confused with atopic dermatitis. It is characterized by erythema and greasy scales and commonly appears on the scalp, also commonly known as “cradle cap”, but may also appear on the face, ears, and neck.7

What Causes
Rashes in Infants?

Vesiculopustular rashes in the neonatal period are commonly caused by bacterial, fungal or viral infections, e.g. Staphylococcus aureus, Candida albicans, or the Herpes simplex virus respectively.8,9 Food allergies are also among the common causes of rash in infants.10


Anna Martinez

Watch leading experts share knowledge on infant rashes

Could It Be a
Symptom of Cow’s
Milk Protein

Skin symptoms account for up to 70% of all symptoms of CMPA11 and atopic dermatitis is the most common rash observed in infants with CMPA.12

However, when considering the diagnosis of CMPA, it’s important to note that the majority of these infants have at least two symptoms affecting at least two different organ systems.13-15

Therefore, it is important to consider the individual child as well as the magnitude of their symptoms.  This can be achieved using an awareness tool such as the Cow’s Milk Related Symptom Score (CoMiSS™) which will help you determine if CMPA might be indicated.16,17

Overview of Symptoms

Respiratory icon


Up to 30% of affected infants with CMPA have respiratory symptoms15,20

Anaphylaxis icon


Anaphylactic shock is a severe, immediate, allergic reaction, which can affect many organ/systems

Skin icon


Up to 75% of infants with CMPA can have skin-related symptoms21

General Symptoms icon


Inconsolable crying is very common in infants with CMPA associated with sleeping problems and food refusal