CMPA Signs and Symptoms

The non-specific signs and symptoms of CMPA, ranging from colic and reflux to constipation, sleeping problems, eczema, diarrhea and crying, make diagnosis a real challenge. The symptoms involve many different organ systems, predominantly the skin, the gastrointestinal and respiratory tracts. The involvement of two or more organ systems increases the likelihood of CMPA.1,2

Every case of CMPA is different, so it helps to be aware of the different symptoms you should be looking out for.


Overview of Symptoms

Respiratory icon


Up to 30% of affected infants with CMPA have respiratory symptoms2,4

Anaphylaxis icon


Anaphylactic shock is a severe, immediate, allergic reaction, which can affect many organ/systems

Skin icon


Up to 75% of infants with CMPA can have skin-related symptoms3

General Symptoms icon


Inconsolable crying is very common in infants with CMPA associated with sleeping problems and food refusal


Discover the experiences that parents/caregivers have had with CMPA in our video series.

01 Adriana and Andre,
London, UK

Adriana tells the story of her baby, André, who presented cow's milk allergy symptoms while she was breastfeeding him. She continued to breastfeed her baby while excluding milk from her diet.

02 Wandrille + Clemence

Meet baby Wandrille, who was diagnosed at 3 months old CMPA after suffering from reflux.

03 Robin + Katrien

Meet Robin, who began showing signs of CMPA at just 1 month old.